Resources

What’s Next in Oligo Manufacturing: Conjugates and Lipid Nanoparticles for Drug Delivery

In vivo drug delivery of oligonucleotides presents significant challenges due to their inherent physicochemical properties and biological barriers. Antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) are large, negatively charged molecules that struggle to cross cell membranes on their own. Once in the bloodstream, they are susceptible to rapid degradation by nucleases and clearance by…